Buy 3-FPM 3-FluoroPhenMetrazine

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Buy 3-FPM 3-FluoroPhenMetrazine

Buy 3-FPM 3-FluoroPhenMetrazine online (also called 3-FPM or PAL-593) is a short-lived stimulant drug of the phenethylamine variety which has recently been made available online. The chemical had no history of human usage prior to 2014 when it began being sold online through research chemical vendors.

3-FPM acts as a norepinephrine-dopamine releasing agent with EC50 values of 30 nM and 43 nM, respectively. It shows only negligible efficacy as a releaser of serotonin, with an EC50 value of 2558 nM.

3-FPM also inhibits uptake mediated by dopamine transporters and norepinephrine transporters in HEK293 cells with potencies comparable to cocaine (IC50 values < 2.5 μM), but with less potent effects at serotonin transporters (IC50 values >80 μM).

At sufficient doses, 3-FPM is capable of reversing monoamine transporters, particularly transporters of the catecholamines dopamine and norepinephrine, and, to a much lesser degree, serotonin transporters, thereby releasing these neurotransmitters from the cytosol into the extracellular space, where they are active.

Evaluation of its metabolic pathway revealed N‐oxidation, aryl hydroxylation and subsequent O‐methylation, alkyl hydroxylation, oxidation, and degradation of the ethyl‐bridge yielding the O/N‐bis‐dealkylated metabolite, combinations thereof and further glucuronidation or sulfations.

Buy 3-FPM 3-FluoroPhenMetrazine

3-FPM 3-FluoroPhenMetrazine is considered to be more subtle in its effects when compared to other stimulants and produces less nervousness, euphoria, and insomnia than drugs of the substituted amphetamine class.
It should be noted that 3-FPM was first named in scientific literature as “PAL-593″; using this name to search for information is more successful than using “3-FPM.”

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